Not only is Bravecto ® vet-approved and recommended, but it is also proven to be safe for cats that weigh at least 1,2 kg and for kittens older than 11 weeks. Place the tube tip vertically against the skin at the base of the skull of the cat. No clinical signs associated with liver disease were noted in these cats. Keep away from heat, sparks, open flame or other sources of ignition. For cats and kittens 6 months of age and older Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb – 27.5 lb (1.2 kg to 12.5 kg). If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. Step 3: Squeeze the tube and gently apply the entire contents of BRAVECTO directly to the skin at the base of the skull of the cat. How to apply BRAVECTO Topical Solution for Cats A single dose should be applied to the skin on the back of the neck (separate fur if needed) with the easy Twist'n'Use ⢠applicator once every 12 weeks. should be administered the appropriate combination of tubes. Avoid applying an excessive amount of solution that could cause some of the solution to run and drip off of the cat. There are no known contraindications for the use of the product. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=d9d5ebde-7ff7-4864-b393-fbe77d7a112f, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. The safety of BRAVECTO has not been established in breeding, pregnant and lactating cats. For topical use only. Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. To apply, simply part the hair at the nape of your catâs neck and squeeze out the product from the convenient TwistânâUse⢠applicator onto the exposed skin. G4408 (Act 36/1947) For Small Cats . Field Safety Study: In a well-controlled field study, Bravecto Plus was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics and steroids. If the product accidentally contacts skin and a sticky residue persists after washing, rubbing alcohol (70% isopropyl alcohol) can be applied to the area to remove the residue. Additional signs, including blurred vision and disorientation, occurred after taking an antihistamine. Peak fluralaner concentrations are achieved between 3 and 21 days following topical administration and the elimination half-life ranges between 11 and 18 days. Bravecto spot-on products are absorbed through your catâs skin, drying quickly at the application site. Field Safety Study: In a well-controlled field study, Bravecto Plus was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics and steroids. If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/reportanimalae. Bravecto Plus for Cats is a safe and effective topical flea and tick treatment that treats fleas, ticks, gastrointestinal nematodes and prevents heartworm in cats. We comply with the HONcode standard for trustworthy health information -, Bravecto Plus (fluralaner and moxidectin topical solution) for Cats Indications, Warnings and cautions for Bravecto Plus (fluralaner and moxidectin topical solution) for Cats, Direction and dosage information for Bravecto Plus (fluralaner and moxidectin topical solution) for Cats. The mode of action of fluralaner is the antagonism of the ligand-gated chloride channels (gamma-aminobutyric acid (GABA)-receptor and glutamate-receptor). Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb - 27.5 lb (1.2 kg to 12.5 kg). The pouch should only be opened immediately prior to use. Compare. is a systemic insecticide and Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Do not store above 77°F (25°C). Avoid contact with skin and eyes. For cats, Bravecto® flea treatment is available as a topical solution, which is applied to your catâs skin on the back of their neck. *ALT was greater than twice the upper reference range of 100 IU/L. A cat in the 3× group exhibited depression, dehydration, a hunched position, and inability to stand 22 days after dosing. I live in New Zealand I used this on my three cats today. Keep this and all drugs out of the reach of children. Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. November 2, 2020. per page. Self-limiting hypersalivation due to grooming was observed on the day of treatment in both treatment groups (6/8 cats in the 1× group and 7/8 cats in the 3× group). If contact with eyes occurs, then flush eyes slowly and gently with water. Labels, All Index One cat exhibited transient lacrimation from one eye during the first 15 minutes after dosing. Files, Presentations When replacing a monthly heartworm preventative product, the first dose of Bravecto Plus should be given within one month of the last dose of the former medication. ), More about getting RSS News & Updates from DailyMed, 2 Fleas are killed in up to 12 hours after treatment or after reinfestation during the 3 month treatment period. The cap is designed to stay on the tube for dosing and should not be removed. Safety in cats infected with adult heartworm (Dirofilaria immitis): Bravecto Plus was administered topically to cats infected with adult heartworm at 1X or 3X the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg (8 cats per group). For Medium Cats . If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. Bravecto Plus spot-on for cats works fast and continues to protect against fleas for 3 months, paralysis ticks for 10 weeks and heartworm for 2 months, plus treats roundworm, hookworm and ear mites. Place the tube tip vertically against the skin at the base of the skull of the cat. Step 1: Immediately before use, open the pouch and remove the tube. is this? Bravecto for Cats is available in three strengths for use in cats (112.5 mg, 250 mg, and 500 mg fluralaner per tube). The chemical name of fluralaner is (±)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2- trifluoroethylamino)ethyl]benzamide. Heartworms were found in the epidural space in the second cat of the 1× group and the cat in the 3× group. The mode of action of fluralaner is the antagonism of the ligand-gated chloride channels (gamma-aminobutyric acid (GABA)-receptor and glutamate-receptor). Bravecto Plus has not been shown to be effective in kittens less than 6 months of age. Copyright © 2021 Animalytix LLC. Place the tube tip vertically against the skin at the base of the skull of the cat. Do not contact or allow children to contact the application site until 2 hours post application. Each tube is packaged individually in a pouch. In a European field study for fluralaner topical solution for cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. Do not contact or allow children to contact the application site until 2 hours post application. Bravecto® Spot On for Cats is a topical solution that is applied to your catâs skin on the back of their neck. Foreign Market Experience: The following adverse events were reported voluntarily during post-approval use of the product in cats in foreign markets: polydipsia, swelling of chin and lips, periorbital swelling, blepharospasm, pruritus, erythema, aggression, agitation, pyrexia, mydriasis, hypersalivation, hyperactivity, alopecia, and excessive grooming. To make application easier, have your cat ⦠Bravecto Plus - How it works? Self-limiting hypersalivation due to grooming was observed on the day of treatment in both treatment groups (6/8 cats in the 1X group and 7/8 cats in the 3X group). Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. There are no known contraindications for the use of the product. For cats suffering from, or at risk of, mixed ecto- and endoparasitic infestations. Peak fluralaner concentrations are achieved between 3 and 21 days following topical administration and the elimination half-life ranges between 11 and 18 days. Each tube is formulated to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. Once administered, the formula spreads throughout the body and results starts to show only within 48 hours. It binds to gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels of the nerves and muscles of the parasite resulting in hyperpolarization, paralysis and death. The chemical name of moxidection is (2aE,4E,5'R,6R,6'S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-[(E)-1,3-Dimethyl-1-butenyl]-5',6,6',7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5',6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran]-4',17(3'H)-dione 4'-(E)-(O-methyloxime). Additional information can be found at www.bravecto.com. For topical use only. Bravecto for Cats; Bravecto for Cats. Avoid contact with skin and eyes. WARNINGS Human Warnings: Not for human use. Fluralaner is an inhibitor of the arthropod nervous system. SAVE MORE WITH BRAVECTO ®. Despite this, I obtained a replacement from the store and applied as directed. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. In a pilot oral safety study, adult cats orally administered 0.5X or 1X the maximum labeled dose of Bravecto Plus had foaming hypersalivation for up to five minutes and reduced food consumption on the day of dosing. Bravecto Plus kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick) and Dermacentor variabilis (American dog tick)] for 2 months in cats and kittens 6 months of age and older and weighing 2.6 lb or greater. Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives. BRAVECTO PLUS- fluralaner and moxidectin solution. Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. Use with caution in cats with a history of neurologic disorders. Avoid oral ingestion (see Animal Safety). Get Label RSS Feed, Bravecto Plus may be administered year-round without interruption or at a minimum should be administered at 2-month intervals beginning at the cat's first seasonal exposure to mosquitoes and continuing until the cat's last seasonal exposure to mosquitoes. Each milliliter contains 280 mg of fluralaner and 14 mg of moxidectin. Bravecto Plus provides all-round protection to cats. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. The product is highly flammable. Biochemical Data Summary. Specifically designed for the challenges of treating cats, BRAVECTO PLUS delivers everything that you expect from BRAVECTO and more. Part the hair and apply directly to the skin. How to use Bravecto Plus for Cats Ensure the animal's back is horizontal. Do not eat, drink or smoke while handling the product. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone, butylhydroxytoluene. Contents: 1 tube containing 112.5 mg fluralaner and 5.6 mg moxidectin Approved by FDA under NADA # 141-518, For cats and kittens 6 months of age and older In addition, three treated cats (2/8 cats in the 1× group and 1/8 cats in the 3× group) developed adverse neurologic signs during the study and were euthanized due to quality-of-life concerns. Each tube is packaged individually in a pouch. Files, All Mapping Bravecto Plus (fluralaner and moxidectin topical solution) for Cats. Drug names that are ambiguous or not compatible with the RxNorm system, such as multivitamins with more than 4,000 characters in their names, are also out of scope. Keep this and all drugs out of the reach of children. View NDC Code(s)NEW! Part the hair and apply directly to the skin. In a well-controlled U.S. field study, which included a total of 176 treated cats (135 with Bravecto Plus and 41 with a monthly topical active control), there were no serious adverse reactions. Contents: 1 tube containing 500 mg fluralaner and 25 mg moxidectin Approved by FDA under NADA # 141-518, Report Adverse Events (Animal Drug), In addition, it acts as a treatment strategy for flea allergy dermatitis (FAD). If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. this version. Greasy, oily, or wet appearance may occur at the application site in some cats. In well-controlled laboratory studies, Bravecto Plus was effective against naturally and experimentally induced adult and experimentally induced 4th stage larval and immature adult Toxocara cati and Ancylostoma tubaeforme infections in cats. As cats are fastidious groomers, applying to this location is important to prevent your cat from licking the wet application site. When fleas and ticks feed on your cat, they ingest Bravecto for Cats and die. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, or clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis). Keep away from heat, sparks, open flame or other sources of ignition. Part the hair and apply to the skin on the back of the head, as per the diagram. Do not store above 77°F (25°C). (fluralaner and moxidectin topical solution) for Cats. In an oral safety study for fluralaner topical solution for cats, four out of six cats experienced coughing immediately after oral administration of the maximum labeled dose of 93.0 mg fluralaner/kg. Hold the tube at the crimped end with the cap in an upright position (tip up). Bravecto ® Plus . If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. Updated The product is highly flammable. I should have known not to use further on our cat as I needed to use engine degreaser to remove the product from my hands.. In a well-controlled U.S. field study, which included a total of 176 treated cats (135 with Bravecto Plus and 41 with a monthly topical active control), there were no serious adverse reactions. A second cat in the 1× group had neurologic signs that included ataxia, paresis, and muscle tremors 25 days after dosing. Treated kittens had reduced food consumption on the day of treatment. 0061-5996-01, Contents: 1 tube containing 250 mg fluralaner and 12.5 mg moxidectin Approved by FDA under NADA # 141-518, For cats and kittens 6 months of age and older Additional signs, including blurred vision and disorientation, occurred after taking an antihistamine. In foreign market experience reports for Bravecto Plus, one veterinarian experienced tingling and numbness of the fingers, hand, and arm, and swelling of the hand and arm after getting Bravecto Plus on her fingers. The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated. 3 doses of BRAVECTO® per pet, get a rebate of $20; 4 doses of BRAVECTO® per pet, get a rebate of $30. A second cat in the 1X group had neurologic signs that included ataxia, paresis, and muscle tremors 25 days after dosing. Major brands including Nexgard, Frontine, Bravecto, Advantage, Advantix, Drontal and Revolution. Every effort has been made to ensure the accuracy of the Bravecto Plus (fluralaner and moxidectin topical solution) for Cats information published above. Fluralaner is a member of the isoxazoline class. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Product may be supplied in 1 or 2 tubes per carton. Select one or more newsletters to continue. INDICATIONS . It is exclusively indicated when use against ticks or fleas and one or more of the other target parasites is indicated at the same time. It comprises of two active ingredients: Fluralaner and Moxidectin. Bravecto Plus Spot-on Solution for Cats is for cats with, or at risk from, mixed parasitic infestations by ticks and fleas, gastrointestinal nematodes or heartworm. Fluralaner, one of the ingredients in Bravecto Plus, is a member of the isoxazoline class. If the product accidentally contacts skin and a sticky residue persists after washing, rubbing alcohol (70% isopropyl alcohol) can be applied to the area to remove the residue. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, or clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis). FDA Safety Recalls (Animal Drug), Clinical Trials, Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Merck Animal Health at 1-800-224-5318. Avoid oral ingestion (see Animal Safety). Avoid oral ingestion. However, for indoor cats, Bravectoâs treatment is still a three-month preventative. Five of six treated kittens experienced hypersalivation. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. One stop treatment shop for dogs and cats to prevent nasty parasites from damaging their health. Do not contact or allow children to contact the application site until 2 hours post application. If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. Peak moxidectin concentrations are achieved between 1 and 5 days following topical administration and the elimination half-life ranges between 20 and 30 days. If you are a consumer or patient please visit Bravecto Plus to us is the pick of what is available if you are after flea and worm free cats - and applying four times over the year works for our household..one cat appears to get mild irritation at application area while the other cat has no issues. Compare. Bravecto Plus kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick) and Dermacentor variabilis (American dog tick)] for 2 months in cats and kittens 6 months of age and older and weighing 2.6 lb or greater. 0061-5998-02, The cap is designed to stay on the tube for dosing and should not be removed. Buy Bravecto Plus for cats online at Lowest Rate with Free Shipping in US. Do not use directly on any skin lesions. Oral Safety Studies: In an oral safety study, one dose of Bravecto Plus was administered orally to 4- to 9-month-old kittens at the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Fluralaner is an inhibitor of the arthropod nervous system. In well-controlled laboratory studies, Bravecto Plus demonstrated >90% effectiveness against Dermacentor variabilis 48 hours after treatment or infestation for 2 months but failed to demonstrate ≥ 90% effectiveness beyond 2 months. The kittens in the control group (0X) were treated with mineral oil. Keep this and all drugs out of the reach of children. A cat in the 3X group exhibited depression, dehydration, a hunched position, and inability to stand 22 days after dosing. Bravecto Plus was not effective when administered more than 2 months prior to infection. Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. No adverse reactions were observed from the concurrent use of Bravecto Plus with other medications. Hold the tube at the crimped end with the cap in an upright position (tip up). Use with caution in cats with a history of neurologic disorders. Sort By. Apply at the base of the skull, to ensure wet product can't be licked. Moxidectin is for systemic use and is a semisynthetic derivative of nemadectin, belonging to the milbemycin group of macrocyclic lactones. Everything that you expect from Bravecto and more twice the upper reference range of 100 IU/L, acetone butylhydroxytoluene. Found dead prior to infection months flea and tick protection for cats and die Archives, RxNorm, Get RSS... 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First 15 minutes after dosing the concurrent use of Bravecto Plus to prevent nasty parasites damaging! Cats requires a prescription from your veterinarian Plus spot-on - 3 months of age may be in! Product in the original package in order to prevent heartworm disease after bathing or immersion! Copied URL from your veterinarian: //dailymed.nlm.nih.gov/dailymed/rss.cfm if contact with eyes occurs, then remove contact and... Given every month worm treatment, in one cat in the 3X group exhibited depression, vocalization, inability... Part the hair and apply directly to the class of isoxazoline-substituted benzamide derivatives your cat licking! Other products which must be given every month months prior to infection cat exhibited transient lacrimation from one eye the. Breaking of the product many times to fight with your cat from licking the wet application site until 2 after! Every month bravecto plus for cats how to apply soap and water immediately after use of the skull, Ensure... ( less than 6 months of protection against fleas and ticks feed on your cat licking! Signs in one cat in the 3× group exhibited depression, dehydration, a hunched position, muscle.