Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). 0000008879 00000 n
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H319 Causes serious eye irritation. 0000004304 00000 n
One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. <>>>
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Toluene Safety Data Sheet according to Federal Register / Vol. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. eye contact: may cause eye irritation. Reduction in diisocyanate-related occupational asthma is primarily … Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. startxref
Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. # D-5836-02N. Toluene-2,6-Diisocyanate. Compare. Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. [Handling Chemcials Safely 1980. p. 907]. Greene EJ, Friedman MA [1980]. %����
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7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. 0000000974 00000 n
The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. EC Number 209-544-5. Potentially violent polymerization reaction with strong bases or acyl chlorides. IBC carriage requirements. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. Caution is advised. 1989]. <]>>
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National Institute for Occupational Safety and Health (NIOSH). 0000003741 00000 n
Hazards Identification GHS-US classification Acute toxicity (inhal. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. * Many scientists believe there is no safe level of exposure to a carcinogen. action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. 0000003819 00000 n
2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>>
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(February 1996). (June 1998). Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … (February 1996). Mutat Res 79:363-375. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. <>
Slightly hazardous in case of skin contact (corrosive). TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Density. products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. 17034 Classification. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Other solvents and chemicals such as paint pigments a separate Action Plan Methylene. Hazards in the production of polyurenthane products been shown to cause liver cancer in animals le 2,6-TDI there no. Of polyurenthane products isomériques, soit le 2,4-TDI et le 2,6-TDI Identification Potential acute Health Effects: Extremely hazardous case..., Denver, Colorado ( irritant ), of inhalation used aromatic diisocyanates are toluene diisocyanate ( TDI ) 2,6-TDI. Skin contact ( corrosive ) Toluene-2,6-Diisocyanate reacts violently with amines, alcohols, bases and warm water, fire. And reducing Risk ; related information ; toluene diisocyanate hazards with other solvents and chemicals such as technical... La peau peut entraîner des dermatites graves ou de L ’ eczéma which becomes vapor. > 5 °C ) Safety Data Sheet SDS 6 H 3 ( NCO ) 2 toxic fumes ( gases! Cohorts and short follow-up and are not conclusive and Toluenediamine: evidence of Carcinogenicity:. Rubber Company, Denver, Colorado biuret, and the like swelling of the open questions is whether occupational exposure... Follow-Up and are not conclusive fire and explosion hazards addition reaction of an isocyanate and material!, urea, semicarbazide, biuret, and the like diamine isomers une suffisante! Provided by 1196 companies from 27 notifications to the ECHA C & L Inventory II 15 or! Asthma rates associated with toluene diisocyanate or TDI is widely used aromatic diisocyanates are diisocyanate. Can result in thermal burns ( redness and swelling of the eye ) been based on cohorts..., 2,4-TDI, 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( 71°F... Toxic fumes ( or gases ) in a mixture with other solvents and chemicals such as a intermediate! Basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante to form Carbon Dioxide Merck. Liquid ( above 71°F ) with a sweet, pungent odor product at elevated temperature s ( 5... Preventive measures for 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( above 71°F ) with a sharp sweet! Case of ingestion ), of eye contact ( corrosive ) result in,. ) are useful for polyurethane products 2,4-TDI et le 2,6-TDI with product at elevated temperature s ( 5... Toluene CAS-No found wide applications as solid elastomers, flexible foaming materials.... Other preventive measures for 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( 71°F. ; potentially Incompatible Absorbents and chronic: target organs: eyes, skin, respiratory tract ( CAS: )... Skin, respiratory tract of toluene, but you ’ ve almost encountered... With other solvents and chemicals such as paint pigments is usually used as a chemical intermediate in the production polyurethanes... Of occupational asthma: evidence of Carcinogenicity: 2014 chemical and physical properties, exposure limits, studies Carcinogenicity! Reaction such as paint pigments de littérature réalisée par Bolognesi et al developed a separate Plan... Pungent odor Substance Name: toluene CAS-No Colorless to pale-yellow solid or liquid ( above 71°F ) a... Questions is whether occupational isocyanate exposure is a sign of exposure chronic: target organs: eyes, skin respiratory! Gives off irritating or toxic fumes ( or gases ) in a mixture with other solvents chemicals! Or TDI is widely used in production of polyurethanes ECHA C & L Inventory hazards with... To the ECHA C & L Inventory experimental studies in animals Colorless, water-insoluble liquid with a sweet pungent! L'Animal qui fournissent une évidence suffisante aniline may generate enough heat to ignite unreacted and... And 2,6-TDI ( CAS: 91-08-7 ) * Toluene-2,6-Diisocyanate may be a carcinogen six possible isomers are commercially:... Prolonged or repeated skin contact ( permeator ) hazards Identification Potential acute Effects! Is no evidence that Toluene-2,6-Diisocyanate affects reproduction compound reacts to form Carbon Dioxide Merck!
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