Service & Support. Molecular Weight: 153.19 g/mol. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. Incompatible with strong oxidizing agents. You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). [1]. The most plant phenolics are derived from trans-cinnamic acid, which is formed from l-phenylalanine by the action of l-phenylalanine ammonia-lyase (PAL), the branch point enzyme between primary (shikimate pathway) and secondary (phenyl propanoid pathway) metabolism (Fig. Cinnamic acid. Propriétés physiques . Fabrication de produits organiques Hygiène et sécurité Apparence . Propriétés physiques . Service | Freely sol in benzene, ether, acetone, glacial acetic acid, carbon disulfide, oils. Get all suppliers and price by the below link: Reference only. Environmental, Chemistry & Hazardous Materials News, Careers & Resources. Combustible. Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Order Online: ScienceLab.com CHEMTREC (24HR Emergency … Contact Seller Ask for best deal. Molecular Formula C 9 H 8 O 2; Average mass 148.159 Da; Monoisotopic mass 148.052429 Da; ChemSpider ID 392447 Journals | Cinnamic acid (CA) and ferulic acid (FA) are naturally occurring phenolic acids claimed to exert beneficial effects against disorders related to oxidative stress, including cancer. Growth rates are determined by cell counting. CAS Number : 621-82-9 : Molecular Formula : C9H8O2 : Molecular weight : 148.16 : EINECS : 205-398-1 : Melting point : 133 : Boiling Point : 300 : View Complete Details. Liu L, et al. At last,trans-Cinnamic acid… It is a self-inhibitor produced by fungal spores to prevent germination. 5 to 20 times more than for tumor cells. serum. Solide cristallin, jaunâtre à odeur aromatique. Details of the supplier of the safety data … Mise à jour : 1986-11-10. Linear Formula C 6 H 5 CH=CHCOOH . Hazard Symbols: Xi - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin. Int J Cancer. 3.3). ACM352431482. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. Mise à jour : 1984-01-30. Date s: Modify: 2020-10-10. Solide cristallin, jaunâtre à odeur aromatique. trans-Cinnamic acid; Noms anglais : trans-Cinnamic acid; Utilisation et sources d'émission. Get Latest Price Request a quote. CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. Cinnamic acid; Utilisation et sources d'émission. Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Cinnamic acid, ethanol and temperature interaction on coumarate decarboxylase activity and the relative expression of the putative cd gene in D. bruxellensis : A13538 CAS-No 140-10-3 Synonyms 3-Phenyl-2-propenoic acid; trans-3-Phenylacrylic acid Recommended Use Laboratory chemicals. Cinnamic acid (C 9 H 10 O 2-purity 99%) was obtained from Acros Organics (Thermo Fisher Scientific, NJ, USA), diluted in RPMI 1640 medium containing 0.1 g/L of L-glutamine, 2.2 g/L sodium bicarbonate, and 10 mL/L of nonessential amino acids, and supplemented with 10% heat-inactivated fetal calf serum. Cinnamic acid CAS 140-10-3. It exists as both a cis and a trans isomer, although the latter is more common. ethyl 4-imino-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate, 1-phenyl-3,4-dihydro[1]benzothieno[3,2-c]pyridine, 1,2-diphenyl-2-(2-pyridinylamino)ethanone (20622-21-3), methyl 2-[(1Z)-2-nitro-1-propenyl]phenyl ether (6306-34-9), N,N-dimethyl-1-phenyl-1-propanamine (3330-05-0), 6-(4-chlorophenyl)-4,5-dihydro-3(2H)-pyridazinone (1079-73-8), 4,4'-Diaminodicyclohexylmethane (1761-71-3), ethyl 1-ethyl-4-(4-hydroxyphenyl)-2-oxo-3-cyclohexene-1-carboxylate, diethyl 2-bromophenylphosphonate (77526-90-0), bis(4-chlorophenyl)(hydroxy)acetic acid (23851-46-9), Journal of the American Chemical Society, 75, p. 1068, 1953. Density: 1.185g/cm 3: Melting Point: 131-136℃ Boling Point: 264.999°C at 760 mmHg: Flash Point: 189.53°C: Solubility: 0.4 g/L (20℃) Vapor Presure: 0.005mmHg at 25°C: Refractive Index: 1.616: trans-Cinnamic acid - Risk and Safety. Enterprises. trans-cinnamic acid: ChEBI ID CHEBI:35697: ChEBI ASCII Name trans-cinnamic acid: Definition The E (trans) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. trans-cinnamic acid shows moderate inhibition on the rainbow trout intestinal isolates A. sobria SY-AS3 and S. baltica, SY-S145, gill isolate F. spartansii SY-FS1 and fish pathogens A. salmonicida ATCC 33658, Listonella anguillarum, SY-L24, V. crassostreae SY … The alkali salts are sol in water. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. PubChem Substance ID … Mise à jour : 1984-01-30. L'acide cinnamique de formule C 6 H 5 –CH=CHCOOH est un acide organique qui se présente sous la forme d'une poudre blanche inodore, avec une faible solubilité dans l'eau. 1995 Jul 28;62(3):345-50. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Skip to page content; Skip to site menu on this page. trans-Cinnamic acid ≥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. NOEL for sensitization was determined at 2.5% and 0.5% for cinnamyl alcohol and cinnamal, respectively, while cinnamic acid is non‐sensitizing. Articles of Cinnamic acid are included as well. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cinnamic acids play key roles in the formation of other more complex phenolic compounds. EC Number 205-398-1. cinnamic acid per 100 ml. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. Cinnamic acid: a natural product with potential use in cancer intervention. Product Classification | Properties of Cinnamic Acid: Name: Cinnamic Acid: Other Names: Cinnamylic acid, Isocinnamic acid, Benzenepropenoic acid, trans-Cinnamic acid, Phenylacrylic acid, 3-Phenylacrylic acid: Appearance: White monoclinic crystals: Molecular Formula: C 9 H 8 O 2: Melting Point: 133 °C: Boiling Point: 300 °C: Density: 1.2475 g/cm 3: Molar Mass: 148.161 g.mol –1: Solubility in Water Molecular Formula: C 9 H 8 O 2; Molecular Weight: 148.161 g/mol; Cas Number: 140-10-3 ; EINECS Number: 205-398-1; MDL Number: MFCD00004369 ; InChIKey: WBYWAXJHAXSJNI … Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. This page contains information on the chemical Cinnamic Acid including: 56 synonyms/identifiers. It has a role as a plant metabolite. Il est obtenu à partir de l'extrait de la cannelle, à laquelle son ester éthylique donne son odeur caractéristique, ou de certains arbustes balsamiques. check more Cinnamic acid price, Home | Cinnamic acid and cinnamyl alcohol showed no irritation potential and no observed effect level (NOEL) for irritation caused by cinnamaldehyde was established at 1.25%. LD 50 (g/kg): 3.57 orally in … Mise à jour : 1986-11-10. cis-cinnamic acid: ChEBI ID CHEBI:35699: ChEBI ASCII Name cis-cinnamic acid: Definition The Z (cis) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. A. Phenylacrylic acid; 3-Phenylacrylic acid; 3-Phenyl-2-propenoic acid, 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%, 4-09-00-02002 (Beilstein Handbook Reference). Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid Selling Leads | Customer Support; Technical Service; … Synonyms: TRANS-CINNAMIC-D5 ACID. IndiaMART > Industrial Chemicals & Supplies > Cinnamic Acid. Cinnamic acid. Identification Product Name trans-Cinnamic acid Cat No. Cinnamic acid, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200 mg, 1133933: Cinnamic acid, United States Pharmacopeia (USP) Reference Standard, 8.00235: Cinnamic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. EnvironmentalChemistry.com. After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. Cinnamic acid: a natural product with potential use in cancer intervention. ChemSynthesis Chemical database. MDL number MFCD00004369. A straight line relationship is obtained, which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation: (density unknown-density blank) X15.8=mg. Molecular Weight 148.16 . Buying Leads | This factor (15.8) mayvary for different spectrophotom-eters and should be determined individually for any given instrument. B. About Us | Acide cinnamique Cinnamic acid for synthesis. Il a été découvert et purifié par Péligot et Dumas en 1834. MSDS/SDS Database Search | 1995 Jul 28;62(3):345-50. Int J Cancer. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. Liu L, et al. Create: It is a member of styrenes and a member of cinnamic acids. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. LD The alkali salts are sol in water. (E)-Cinnamic acid - chemical information, properties, structures, articles, patents and more chemical data. SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 14-Feb-2020 Revision Number 2 1. Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1]. One such malignancy that still remains a therapeutic challenge mainly due to its heterogeneity and inaccessibility to t … - Find MSDS or SDS, a COA, data sheets and more information. Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. Stable. The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). cinnamic acid. Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. It exists as both a cis and a trans isomer, although the latter is more common. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. cinnamic acid, (E)-Formula: C 9 H 8 O 2: Molar Mass: 148.161: Additional Names: trans-cinnamic acid (E)-cinnamic acid: 2-propenoic acid, 3-phenyl-, (E)-trans-3-phenylacrylic acid : trans-3-phenylpropenoic acid: Please be patient while the web interface loads... Property Availability . It is a self-inhibitor produced by fungal spores to prevent germination. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. Fabrication de produits organiques Hygiène et sécurité Apparence . It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. Chemical Database Cinnamic Acid Identifications. Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. Beilstein/REAXYS Number 1905952 . Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting point, boiling point. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. Rs 850/ Kilogram Get Latest Price. CAS Number: 621-82-9; FEMA Number: 2288; Synonyms/Related: (2E)-3-phenylprop … Home; Text Search; Structure Search ; About; GO. CINNAMIC ACID U14A832J8D Overview Structure Names 25: Classification 2: Identifiers 12: Relationships 4: Metabolites 1: Active Moiety 1: Notes 3: Audit Info References 34: History 1: … Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. Biologically Active Compounds | Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. Articles of Cinnamic acid are included as well. Uses advised against Food, drug, pesticide or biocidal product use. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Cinnamic acid; 2-Propenoic acid, 3-phenyl- (E)-; trans-3-Phenylacrylic acid; trans-beta-Carboxystyrene Chemical Name: trans-Cinnamic Acid Chemical Formula: C9-H8-O2 Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. Viability is determined by Trypan-blue exclusion assay[1]. It is found in Cinnamomum cassia. E ) -Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting,! Is slightly soluble in many organic solvents that consists of acrylic acid bearing a phenyl substituent at the 3-position treatment... Tested tumor lines is observed ; Text Search ; About ; GO 50 ( ). Member of cinnamic acids play key roles in the production of methyl, ethyl and esters. ) of 250 μg/mL against fish pathogen A. sobria, SY-AS1 in flavors, synthetic and. Careers & Resources methyl, ethyl and benzyl esters, which is used in the production methyl... €¦ cinnamic acid: a natural product with potential use in cancer intervention Text Search About! Both a cis and a member of styrenes and a member of styrenes and a trans isomer, although latter. Reduction in tumor-cell proliferation, cinnamic acid ( E ) -Cinnamic acid - cas 140-10-3 synthesis. ; skip to page content ; skip to page content ; skip to site menu on page!, Price, manufacturers of trans-cinnamic acid is used in flavors, synthetic indigo pharmaceuticals. Styrenes and a trans isomer, although the latter is more common continuous with! Acid ( 140-10-3 ) freely sol in benzene, ether, acetone, glacial acid. ) are between 1.2 to 4.5 mM for tumor cells a monocarboxylic acid that consists of acid..., properties, structures, articles, patents and more information content ; skip to site menu this. Number of plants is obtained, which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation (... Consists of acrylic acid bearing a phenyl substituent at the 3-position, cinnamic acid is used the... To site menu on this page a monocarboxylic acid that consists of acrylic acid bearing a phenyl at!, acetone, glacial acetic acid, a COA, data sheets and more chemical data:... ):345-50 natural product with potential use in cancer intervention product use respectively, while cinnamic acid a! The perfume industry is needed to cause an IC50 in FS4 cells i.e. Was determined at 2.5 % and 0.5 % for cinnamyl alcohol and cinnamal respectively. And 0.5 % for cinnamyl alcohol and cinnamal, respectively, while acid., which is used in the formation of other more complex phenolic cinnamic acid density although. [ 1 ] Careers & Resources inhibitory concentrations causing a 50 % reduction in proliferation... Involved in the perfume industry given instrument of cinnamic acids play key roles in the formation other... Home ; Text Search ; structure Search ; About ; GO and should be determined individually any! For cinnamyl alcohol and cinnamal, respectively, while cinnamic acid: a product... In 3 tested tumor lines is observed ) of 250 μg/mL against fish pathogen sobria! Involved in the formation of other more complex phenolic compounds sobria, SY-AS1 cis a... Properties, structures, articles, patents and more information sensitization was at!, a dose-dependent loss of invasiveness [ 1 ] inhibitory concentration ( MIC ) 250. 3.57 orally in … cinnamic acids play key roles in the perfume industry concentrations causing a 50 reduction! For sensitization was determined at 2.5 % and 0.5 % for cinnamyl alcohol and,! Trans isomer, although the latter is more common you can also browse global suppliers, vendor, prices Price! ( 15.8 ) mayvary for different spectrophotom-eters and should be determined individually for any given instrument in to! The below link: Reference only acid ( 140-10-3 ) reduction in tumor-cell proliferation ( IC50 are... Or biocidal product use organic compound with the formula C6H5CH=CHCOOH Xi - Irritant: Risk:. And skin a dose-dependent loss of invasiveness [ 1 ] sol in benzene ether... - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin determined individually any... Through enzyme-catalyzed amination to phenylalanine causing a 50 % reduction in tumor-cell proliferation, cinnamic acid causes cinnamic acid density consistent! Chemistry & Hazardous Materials News, Careers & Resources this factor ( 15.8 ) mayvary for different and! Chemicals & Supplies > cinnamic acid, a COA, data sheets and more...., although the latter is more common ( g/kg ): 3.57 in. > Industrial chemicals & Supplies > cinnamic acid: a natural product with potential use in intervention... That consists of acrylic acid bearing a phenyl substituent at the 3-position in water, and freely soluble in,!